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[Pharmacokinetics of recombinant pro-urokinase ocular dosage form].
- Source :
-
Vestnik oftalmologii [Vestn Oftalmol] 1998 Jan-Feb; Vol. 114 (1), pp. 38-41. - Publication Year :
- 1998
-
Abstract
- Thrombolytic enzymes are widely used in the treatment of vascular diseases of the eyes and of intraocular hemorrhages. We studied the pharmacokinetics of recombinant prourokinase (proRUK) in ocular structures after its intravitreal administration and subtenon's implantation of collagen infusion system (SICIS). Kinetic parameters of accumulation of labeled proRUK in ocular structures were obtained. After intravitreal administration, the proRUK half-life (T1/2) was 7.9 +/- 1.44 h, with proRUK losing none of its enzymatic activity while in the vitreous body. The maximum accumulation of proRUK in the vitreous administered by the SICIS is observed after 4-5 h and is 1.5-2.0% of the dose administered. In the sclera the maximum accumulation of proRUK is 10-15% (4-6 h after administration), in the vascular membrane 0.8% (4 h after administration). We believe that combination of intravitreal and SICIS-aided administration of proRUK to patients with extensive hemorrhages (subtotal and total hemopthalmia) will improve the efficacy of therapy.
- Subjects :
- Animals
Chinchilla
Dose-Response Relationship, Drug
Enzyme Precursors administration & dosage
Eye drug effects
Eye Hemorrhage drug therapy
Eye Hemorrhage metabolism
Fibrinolytic Agents administration & dosage
Follow-Up Studies
Infusion Pumps, Implantable
Injections
Rabbits
Recombinant Proteins administration & dosage
Recombinant Proteins pharmacokinetics
Urokinase-Type Plasminogen Activator administration & dosage
Vitreous Body
Enzyme Precursors pharmacokinetics
Eye metabolism
Fibrinolytic Agents pharmacokinetics
Urokinase-Type Plasminogen Activator pharmacokinetics
Subjects
Details
- Language :
- Russian
- ISSN :
- 0042-465X
- Volume :
- 114
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Vestnik oftalmologii
- Publication Type :
- Academic Journal
- Accession number :
- 9584640