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Prolonged treatment with beta-adrenoceptor antagonists counteracts the aggression deficit induced by chronic stress.
- Source :
-
Polish journal of pharmacology [Pol J Pharmacol] 1997 Sep-Oct; Vol. 49 (5), pp. 283-9. - Publication Year :
- 1997
-
Abstract
- Chronic stress-induced behavioral disturbances have been used as experimental models of depression. One of them is the deficit of fighting behavior induced by 16-day application of various unpredictable stressors. In the present study we investigated the effect of beta-adrenoceptor antagonists (propranolol, pindolol, nadolol and acebutolol) on electric footshock-induced fighting behavior in chronically stressed (14 various stressors over 16 days) male Wistar rats. It was found that the number of fighting attacks was reduced by about 50-80% in the rats submitted to chronic stress. Prolonged, 14-day, but not acute, treatment with propranolol, pindolol or nadolol (but not acebutolol) counteracted the deficit of aggression induced by chronic stress. It is suggested that beta-adrenoceptor antagonists which penetrate the blood-brain barrier may prevent the behavioral changes induced by chronic stress.
- Subjects :
- Acebutolol administration & dosage
Acebutolol pharmacology
Adrenergic beta-Antagonists administration & dosage
Animals
Chronic Disease
Exploratory Behavior drug effects
Male
Nadolol administration & dosage
Nadolol pharmacology
Pindolol administration & dosage
Pindolol pharmacology
Propranolol administration & dosage
Propranolol pharmacology
Rats
Rats, Wistar
Time Factors
Adrenergic beta-Antagonists pharmacology
Aggression drug effects
Stress, Physiological physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1230-6002
- Volume :
- 49
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Polish journal of pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 9566026