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HLA-antigens in black patients with hepatocellular carcinoma.
- Source :
-
East African medical journal [East Afr Med J] 1997 Nov; Vol. 74 (11), pp. 705-7. - Publication Year :
- 1997
-
Abstract
- To determine whether genetically determined immune response factors could be involved in the pathogenesis of hepatocellular carcinoma, we performed HLA-A and HLA-B typing in 55 black patients with histologically-proven hepatocellular carcinoma, and HLA-DR and HLA-DQ typing in 47 of these patients. The HLA typing was also carried out in a control group of normal black patients. The HLA typing was done by a standard microlymphocytotoxicity method. No difference in HLA-A, HLA-DR and HLA-DQ frequencies between patients and controls were noted. HLA-B21 was present in 10.9% of patients compared to 1.8% of control subjects (corrected p < 0.005; relative risk = 6.6) and HLA-B49 was present in 7.3% of patients compared with 1.1% of normal control subjects (corrected p < 0.007; relative risk = 7.1). These findings suggest that genetic factors may play a role in the pathogenesis of hepatocellular carcinoma.
- Subjects :
- Adult
Carcinoma, Hepatocellular blood
Carcinoma, Hepatocellular genetics
Case-Control Studies
Histocompatibility Testing
Humans
Liver Neoplasms blood
Liver Neoplasms genetics
Risk
South Africa
Black People genetics
Carcinoma, Hepatocellular immunology
HLA-A Antigens blood
HLA-B Antigens blood
HLA-DQ Antigens blood
HLA-DR Antigens blood
Liver Neoplasms immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0012-835X
- Volume :
- 74
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- East African medical journal
- Publication Type :
- Academic Journal
- Accession number :
- 9557441