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[Pulmonary artery hypertension in HIV seropositive drug addicts. Apropos of 10 cases].
- Source :
-
Revue des maladies respiratoires [Rev Mal Respir] 1998 Feb; Vol. 15 (1), pp. 97-102. - Publication Year :
- 1998
-
Abstract
- Pulmonary hypertension (PH) is a classic complication associated with intravenous drug addiction. Various pathogenic mechanisms may be involved but HIV infection now appears to be the main etiologic factor. We report herein 10 case of PH occurred in HIV+ intravenous drug abusers. Each patient had several pathogenic factors: HIV infection, pills crushed and intravenously injected (6 cases), heavy and repeated consumption of amphetamines and cocaine (6 cases), cirrhosis with portal hypertension (2 cases), anticardiolipid antibodies (2 cases). The clinical findings were similar to those reported for PH in HIV seronegative patients; however, in 5 cases, opiates could have alleviated dyspnea, which became perceptible only at the time of drug withdrawal. Because drug addicts usually exhibit a weak support for medical prescriptions, long term therapy needing regular follow-up such as anticoagulation appears to be hazardous and even dangerous. The prognosis remains poor, since the progression of PH led to the death of one third patients within the year following the diagnosis.
- Subjects :
- Adult
Amphetamine-Related Disorders complications
Antibodies, Anticardiolipin blood
Anticoagulants
Cause of Death
Cocaine-Related Disorders complications
Contraindications
Disease Progression
Drug Prescriptions
Dyspnea drug therapy
Female
Follow-Up Studies
HIV Seronegativity
Humans
Male
Middle Aged
Narcotics therapeutic use
Prognosis
Respiratory System Agents therapeutic use
Substance Withdrawal Syndrome drug therapy
Survival Rate
HIV Seropositivity complications
Hypertension, Pulmonary etiology
Pulmonary Artery
Substance Abuse, Intravenous complications
Subjects
Details
- Language :
- French
- ISSN :
- 0761-8425
- Volume :
- 15
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Revue des maladies respiratoires
- Publication Type :
- Academic Journal
- Accession number :
- 9551521