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Concentration-dependent actions of a new indene derivative, TN-871, in the enteric nervous system.
- Source :
-
European journal of pharmacology [Eur J Pharmacol] 1998 Jan 26; Vol. 342 (2-3), pp. 167-75. - Publication Year :
- 1998
-
Abstract
- Intracellular electrical recordings and fluorimetric measurement of intracellular Ca2+ concentration ([Ca2+]i) were made from enteric neurons of the guinea-pig myenteric and submucosal plexuses to examine the actions of 2-n-butyl-1-(4-methylpiperazinyl)5,6-ethylendioxyindene x 2HCl (TN-871) on neural activity in the single cell. TN-871 affected neuronal electrophysiological properties and synaptic transmission in the enteric nervous system in a concentration-dependent manner; TN-871 at lower concentrations hyperpolarized enteric neurons and/or facilitated synaptic transmission, whereas at higher concentrations it depolarized enteric neurons and/or inhibited synaptic transmission. Experiments with fura-2 showed that TN-871 modulated both resting [Ca2+]i and [Ca2+]i-transient associated with action potentials. Thus, the present results demonstrated that TN-871 at lower concentrations facilitates but at higher concentrations depresses Ca2+-dependent or Ca2+-involving processes, suggesting that TN-871 may affect the Ca2+ dynamics in enteric neurons either directly, indirectly or both.
- Subjects :
- Action Potentials drug effects
Animals
Calcium Channels drug effects
Calcium Channels metabolism
Enteric Nervous System cytology
Evoked Potentials, Somatosensory drug effects
Guinea Pigs
In Vitro Techniques
Indenes administration & dosage
Indenes pharmacokinetics
Membrane Potentials drug effects
Microelectrodes
Neurons drug effects
Neurons metabolism
Spectrometry, Fluorescence
Synaptic Transmission drug effects
Enteric Nervous System drug effects
Indenes pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0014-2999
- Volume :
- 342
- Issue :
- 2-3
- Database :
- MEDLINE
- Journal :
- European journal of pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 9548382
- Full Text :
- https://doi.org/10.1016/s0014-2999(97)01436-2