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T helper 1 (Th1) and Th2 characteristics start to develop during T cell priming and are associated with an immediate ability to induce immunoglobulin class switching.
- Source :
-
The Journal of experimental medicine [J Exp Med] 1998 Apr 20; Vol. 187 (8), pp. 1193-204. - Publication Year :
- 1998
-
Abstract
- The respective production of specific immunoglobulin (Ig)G2a or IgG1 within 5 d of primary immunization with Swiss type mouse mammary tumor virus [MMTV(SW)] or haptenated protein provides a model for the development of T helper 1 (Th1) and Th2 responses. The antibody-producing cells arise from cognate T cell B cell interaction, revealed by the respective induction of Cgamma2a and Cgamma1 switch transcript production, on the third day after immunization. T cell proliferation and upregulation of mRNA for interferon gamma in response to MMTV(SW) and interleukin 4 in response to haptenated protein also starts during this day. It follows that there is minimal delay in these responses between T cell priming and the onset of cognate interaction between T and B cells leading to class switching and exponential growth. The Th1 or Th2 profile is at least partially established at the time of the first cognate T cell interaction with B cells in the T zone. The addition of killed Bordetella pertussis to the hapten-protein induces nonhapten-specific IgG2a and IgG1 plasma cells, whereas the anti-hapten response continues to be IgG1 dominated. This indicates that a Th2 response to hapten-protein can proceed in a node where there is substantial Th1 activity.
- Subjects :
- Animals
Bordetella pertussis immunology
Germinal Center immunology
Haptens immunology
Interferon-gamma biosynthesis
Interleukin-4 biosynthesis
Lymph Nodes cytology
Lymph Nodes immunology
Mammary Tumor Virus, Mouse immunology
Mice
Mice, Inbred BALB C
Plasma Cells
Spleen cytology
Spleen immunology
gamma-Globulins immunology
Immunoglobulin Class Switching
Lymphocyte Activation
Th1 Cells
Th2 Cells
Vaccination
Subjects
Details
- Language :
- English
- ISSN :
- 0022-1007
- Volume :
- 187
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- The Journal of experimental medicine
- Publication Type :
- Academic Journal
- Accession number :
- 9547331
- Full Text :
- https://doi.org/10.1084/jem.187.8.1193