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Asymmetry of basal ganglia glucose metabolism and dopa responsiveness in parkinsonism.
- Source :
-
Movement disorders : official journal of the Movement Disorder Society [Mov Disord] 1998 Mar; Vol. 13 (2), pp. 275-80. - Publication Year :
- 1998
-
Abstract
- We investigated, by positron emission tomography (PET) with [18F]fluoro-2-deoxy-d-glucose (FDG) (FDG-PET), brain glucose metabolism in 19 patients with parkinsonian features. We compared local pattern of FDG uptake and asymmetry indexes in patients with therapeutic response to levodopa (L-dopa) (group 1, presumed Parkinson's disease, n = 9) and patients without L-dopa therapeutic response (group 2, presumed striatonigral degeneration, n = 10). Limb dystonia was present in 11% of patients in group 1 and in 40% of patients in group 2. Asymmetry in basal ganglia metabolism was distributed differently in the two groups (analysis of variance, p < 0.04). In superior and inferior putamen, superior and middle caudate, ventral striatum, and inferior thalamus, relative reduction in metabolism on the side contralateral to predominant parkinsonian signs was associated with L-dopa unresponsiveness. On the contrary, in middle caudate, ventral striatum, and inferior thalamus, a relative increase in metabolism on the side contralateral to the predominant side, parkinsonian signs were found in L-dopa-responsive patients. Our FDG-PET study using simple statistical procedures demonstrates inverse asymmetry of basal ganglia glucose metabolism in parkinsonian patients grouped on the sole basis of L-dopa responsiveness.
- Subjects :
- Adult
Aged
Antiparkinson Agents adverse effects
Basal Ganglia diagnostic imaging
Brain Mapping
Dominance, Cerebral physiology
Energy Metabolism physiology
Female
Fluorodeoxyglucose F18 metabolism
Humans
Levodopa adverse effects
Male
Middle Aged
Motor Skills drug effects
Motor Skills physiology
Multiple System Atrophy diagnostic imaging
Multiple System Atrophy drug therapy
Neurologic Examination drug effects
Parkinson Disease diagnostic imaging
Treatment Outcome
Antiparkinson Agents therapeutic use
Basal Ganglia drug effects
Blood Glucose metabolism
Dominance, Cerebral drug effects
Energy Metabolism drug effects
Levodopa therapeutic use
Parkinson Disease drug therapy
Tomography, Emission-Computed
Subjects
Details
- Language :
- English
- ISSN :
- 0885-3185
- Volume :
- 13
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Movement disorders : official journal of the Movement Disorder Society
- Publication Type :
- Academic Journal
- Accession number :
- 9539341
- Full Text :
- https://doi.org/10.1002/mds.870130213