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Cardiovascular risk factors in people with different genotypes in the insertion/deletion (I/D) polymorphism at the locus for angiotensin I-converting enzyme (ACE).
- Source :
-
Clinical genetics [Clin Genet] 1997 Dec; Vol. 52 (6), pp. 422-6. - Publication Year :
- 1997
-
Abstract
- The deletion (D) allele of an insertion/deletion (I/D) polymorphism at the locus for angiotensin I-converting enzyme (ACE) has been reported to be an independent risk factor for myocardial infarction (MI), particularly in people lacking traditional risk factors. Furthermore, a borderline association between Lp(a) lipoprotein level and the I/D polymorphism at the ACE locus was reported in one study. We have searched for possible "level gene" or "variability gene" effects of ACE genes on Lp(a) lipoprotein, total cholesterol (TC), high density lipoprotein (HDL) cholesterol (HDLC), low density lipoprotein (LDL) cholesterol (LDLC), triglycerides (TG), apolipoprotein B (apoB), apolipoprotein A-I (apoA-I), and body mass index (BMI). None of these variables differed significantly between genotypes in the I/D polymorphism in any of three population samples. A single population sample created by combining the three series, exhibited an insignificant trend towards individuals carrying the D-allele having a higher level of Lp(a) lipoprotein than those lacking it, and DD homozygotes had a significantly higher Lp(a) lipoprotein level than the combined group of ID/II individuals (p = 0.03). These results may indicate that the D-allele of the I/D polymorphism at the ACE locus could influence the level of Lp(a) lipoprotein.
- Subjects :
- Adult
Apolipoproteins blood
Body Mass Index
Cholesterol blood
Cholesterol, HDL blood
Cholesterol, LDL blood
Female
Gene Deletion
Gene Frequency
Genotype
Humans
Male
Middle Aged
Risk Factors
Triglycerides blood
Twins, Monozygotic
Lipids blood
Lipoprotein(a) blood
Myocardial Infarction etiology
Peptidyl-Dipeptidase A genetics
Polymorphism, Genetic
Subjects
Details
- Language :
- English
- ISSN :
- 0009-9163
- Volume :
- 52
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Clinical genetics
- Publication Type :
- Academic Journal
- Accession number :
- 9520252
- Full Text :
- https://doi.org/10.1111/j.1399-0004.1997.tb02562.x