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Helicases: a unifying structural theme?

Authors :
Bird LE
Subramanya HS
Wigley DB
Source :
Current opinion in structural biology [Curr Opin Struct Biol] 1998 Feb; Vol. 8 (1), pp. 14-8.
Publication Year :
1998

Abstract

The recent structure determinations of PcrA DNA helicase, NS3 RNA helicase, and Rep DNA helicase have revealed similarities between their folds. When these data are examined with sequence and biochemical analyses, as well as microscopy studies of hexameric helicases, a picture of a unifying structure and mechanism for all helicases is beginning to emerge.

Subjects

Subjects :
DNA metabolism
DNA Helicases classification
DNA Helicases metabolism
Models, Molecular
Protein Folding
Structure-Activity Relationship
DNA Helicases chemistry

Details

Language :
English
ISSN :
0959-440X
Volume :
8
Issue :
1
Database :
MEDLINE
Journal :
Current opinion in structural biology
Publication Type :
Academic Journal
Accession number :
9519291
Full Text :
https://doi.org/10.1016/s0959-440x(98)80004-3
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