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A distinct region of chromosome 19p13.3 associated with the sporadic form of adenoma malignum of the uterine cervix.
- Source :
-
Cancer research [Cancer Res] 1998 Mar 15; Vol. 58 (6), pp. 1140-3. - Publication Year :
- 1998
-
Abstract
- Adenoma malignum (AM) is known to be one of the malignant tumors that is commonly associated with Peutz-Jeghers syndrome. Recently, the genetic locus of Peutz-Jeghers syndrome was mapped to the telomeric region of chromosome 19p. We analyzed nine sporadic cases of AM with high-density loss of heterozygosity to study the region of chromosome 19p13.2-13.3 using eight microsatellite markers. Our deletion mapping data revealed a distinct region with 100% loss of heterozygosity frequency at marker D19S216. This result indicates that a putative tumor suppressor gene for AM is located at D19S216 on chromosomal band 19p13.3 and plays an important role in AM tumorigenesis.
Details
- Language :
- English
- ISSN :
- 0008-5472
- Volume :
- 58
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Cancer research
- Publication Type :
- Academic Journal
- Accession number :
- 9515797