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Strontium absorption and excretion in normocalciuric subjects: relation to calcium metabolism.
- Source :
-
Clinical chemistry [Clin Chem] 1998 Mar; Vol. 44 (3), pp. 586-90. - Publication Year :
- 1998
-
Abstract
- The relationships of Sr intestinal absorption and renal excretion with biohumoral factors regulating Ca metabolism were studied in 47 normocalciuric subjects with Ca kidney stones. Sr concentrations were measured in serum and urine after an oral load of stable Sr (30.2 mumol/kg body wt). Enteral absorption of the ion (9.77 +/- 0.438 mmol.L-1.min, 240 min after Sr administration), expressed as the area under the plasma concentration-time curve (AUC), and renal clearance (CRE) in these subjects during the test (2.80 +/- 0.336 mL/min) were not different from values for 27 controls. CRE was not correlated with AUCs. Plasma concentrations of parathyroid hormone (PTH) negatively correlated with AUCs (P < 0.01) and correlated with CRE after one outlier was excluded (P < 0.05). Plasma concentrations of 1,25-dihydroxyvitamin D correlated positively with AUCs (P < 0.01) when normalized to the plasma concentration of PTH. Multiple stepwise regression showed that PTH and phosphatemia were significantly related to AUC values at 240 min (P < 0.01). These findings suggest that Sr absorption and excretion reflect the regulation of Ca metabolism, but some differences in renal handling of the two ions may exist.
- Subjects :
- Administration, Oral
Adult
Calcitriol blood
Calcium blood
Calcium urine
Calcium Oxalate
Creatinine blood
Creatinine urine
Female
Humans
Immunoradiometric Assay
Intestinal Absorption
Kidney Calculi chemistry
Kidney Calculi urine
Male
Metabolic Clearance Rate
Phosphates blood
Phosphates urine
Radioligand Assay
Reference Values
Regression Analysis
Sodium blood
Sodium urine
Spectrophotometry, Atomic
Strontium administration & dosage
Calcium metabolism
Kidney Calculi metabolism
Parathyroid Hormone blood
Strontium pharmacokinetics
Subjects
Details
- Language :
- English
- ISSN :
- 0009-9147
- Volume :
- 44
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Clinical chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 9510866