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Association between HLA-A1 allele and schizophrenia gene(s) in patients refractory to conventional neuroleptics but responsive to clozapine medication.
- Source :
-
Tissue antigens [Tissue Antigens] 1998 Feb; Vol. 51 (2), pp. 200-3. - Publication Year :
- 1998
-
Abstract
- We report an association between HLA-A1 allele and a subgroup of schizophrenic patients refractory to conventional neuroleptic treatment but responsive to clozapine. The frequency of HLA-A1 was 58% among the schizophrenic patients not responding to conventional treatment but responsive to clozapine but only 10.5% among the patients responding to conventional neuroleptics. The HLA-A1 occurs in 20% of the random Finnish population. Our results indicate that HLA-A1 defines a subgroup of schizophrenic patients with a selective response to neuroleptics.
Details
- Language :
- English
- ISSN :
- 0001-2815
- Volume :
- 51
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Tissue antigens
- Publication Type :
- Academic Journal
- Accession number :
- 9510376
- Full Text :
- https://doi.org/10.1111/j.1399-0039.1998.tb02965.x