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An experimental pilot study of tacalcitol activities during modulation of parakeratotic skin features.
- Source :
-
Cellular and molecular biology (Noisy-le-Grand, France) [Cell Mol Biol (Noisy-le-grand)] 1997 Dec; Vol. 43 (8), pp. 1213-20. - Publication Year :
- 1997
-
Abstract
- Establishing guidelines and experimental models preclinical and clinical evaluations of new agents for treatment, and/or prevention of human diseases has become a task of crucial importance. Psoriasis is such one disease holding great interest for dermatology owing to its high rate of incidence and complexity of treatment. However the absence of psoriatic lesions in animals and the inability to induce them, calls for experimental techniques both in vitro and in vivo. The purpose of this study was to evaluate experimentally the effects of tacalcitol on cell proliferation and differentiation process. Thereafter a human pilot study on psoriatic patients has been developed.
- Subjects :
- Administration, Topical
Adult
Animals
Disease Models, Animal
Female
Humans
Male
Mice
Middle Aged
Parakeratosis pathology
Pilot Projects
Psoriasis pathology
Skin pathology
Anti-Inflammatory Agents therapeutic use
Dihydroxycholecalciferols therapeutic use
Parakeratosis drug therapy
Psoriasis drug therapy
Skin drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0145-5680
- Volume :
- 43
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Cellular and molecular biology (Noisy-le-Grand, France)
- Publication Type :
- Academic Journal
- Accession number :
- 9489947