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Is ACTH a key to understanding anticonvulsant action?
- Source :
-
Developmental medicine and child neurology [Dev Med Child Neurol] 1998 Feb; Vol. 40 (2), pp. 82-9. - Publication Year :
- 1998
-
Abstract
- Adrenocorticotrophin hormone (ACTH) has been used as an anticonvulsant for many years. In this paper, the use of ACTH in 23 children with intractable epilepsies is described. It was found that ACTH worked most effectively when the EEG showed benzodiazepine sensitivity. A mechanism of action of ACTH is proposed.
- Subjects :
- Adenosine metabolism
Adrenocorticotropic Hormone pharmacology
Anticonvulsants pharmacology
Benzodiazepines therapeutic use
Binding Sites
Child
Child, Preschool
Cohort Studies
Diazepam therapeutic use
Electroencephalography
Epilepsy diagnosis
Female
Follow-Up Studies
Humans
Infant
Male
Receptors, GABA-A drug effects
Severity of Illness Index
gamma-Aminobutyric Acid metabolism
Adrenocorticotropic Hormone adverse effects
Anticonvulsants adverse effects
Epilepsy drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0012-1622
- Volume :
- 40
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Developmental medicine and child neurology
- Publication Type :
- Academic Journal
- Accession number :
- 9489495
- Full Text :
- https://doi.org/10.1111/j.1469-8749.1998.tb15366.x