Back to Search
Start Over
Dietary maltitol decreases the incidence of 1,2-dimethylhydrazine-induced cecum and proximal colon tumors in rats.
- Source :
-
The Journal of nutrition [J Nutr] 1998 Mar; Vol. 128 (3), pp. 536-40. - Publication Year :
- 1998
-
Abstract
- Maltitol is fermented in the colon due to only partial hydrolysis in the small intestine. In the present study, we examined effects of dietary maltitol on dimethylhydrazine-induced intestinal tumor in rats. In experiment 1, rats were fed a fiber-free diet or diets supplemented with 1 or 5 g/100 g maltitol for 27 wk. Each group of rats was injected with dimethylhydrazine or vehicle alone for the first 14 wk of the experimental period. Maltitol supplementation at 1 g/100 g of the diet significantly reduced tumor incidence in the cecum and the 5% supplement reduced tumor incidence in both the cecum and proximal colon in dimethylhydrazine-treated rats. In experiment 2, we investigated the effect of the 1 g/100 g maltitol diet on the short chain fatty acid concentrations in cecal contents of placebo and dimethylhydrazine-treated rats. Intake of the 1 g/100 g maltitol diet doubled (P < 0.05) the concentration of butyrate but did not affect acetate or propionate in the cecal contents. These results suggest that dietary maltitol has a protective effect against dimethylhydrazine-induced tumors in rat cecum and proximal colon and that butyrate produced by bacterial fermentation of maltitol in the cecum may be involved in the protection.
- Subjects :
- Animals
Body Weight physiology
Cecum physiology
Diet
Eating physiology
Fatty Acids, Volatile analysis
Gastrointestinal Contents chemistry
Hydrogen-Ion Concentration
Incidence
Male
Maltose pharmacology
Rats
Rats, Inbred F344
1,2-Dimethylhydrazine
Carcinogens
Cecal Neoplasms chemically induced
Cecal Neoplasms prevention & control
Colonic Neoplasms chemically induced
Colonic Neoplasms prevention & control
Maltose analogs & derivatives
Sugar Alcohols pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0022-3166
- Volume :
- 128
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The Journal of nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 9482760
- Full Text :
- https://doi.org/10.1093/jn/128.3.536