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CD4+ T cell-mediated granulomatous pathology in schistosomiasis is downregulated by a B cell-dependent mechanism requiring Fc receptor signaling.
- Source :
-
The Journal of experimental medicine [J Exp Med] 1998 Feb 16; Vol. 187 (4), pp. 619-29. - Publication Year :
- 1998
-
Abstract
- The effector functions of CD4+ T lymphocytes are generally thought to be controlled by distinct populations of regulatory T cells and their soluble products. The role of B cells in the regulation of CD4-dependent host responses is less well understood. Hepatic egg granuloma formation and fibrosis in murine schistosomiasis are dependent on CD4+ lymphocytes, and previous studies have implicated CD8+ T cells or cross-regulatory cytokines produced by T helper (Th) lymphocytes as controlling elements of this pathologic process. In this report, we demonstrate that B cell-deficient (muMT) mice exposed to Schistosoma mansoni develop augmented tissue pathology and, more importantly, fail to undergo the spontaneous downmodulation in disease normally observed during late stages of infection. Unexpectedly, B cell deficiency did not significantly alter T cell proliferative response or cause a shift in the Th1/Th2 balance. Since schistosome-infected Fc receptor-deficient (FcR gamma chain knockout) mice display the same exacerbated egg pathology as that observed in infected muMT mice, the B cell- dependent regulatory mechanism revealed by these experiments appears to require receptor-mediated cell triggering. Together, the data demonstrate that humoral immune response/FcR interactions can play a major role in negatively controlling inflammatory disease induced by CD4+ T cells.
- Subjects :
- Animals
B-Lymphocytes immunology
Granuloma immunology
Granuloma parasitology
Liver immunology
Liver parasitology
Liver pathology
Liver Diseases immunology
Liver Diseases parasitology
Liver Diseases pathology
Mice
Mice, Inbred C57BL
Mice, Knockout
Ovum immunology
Schistosomiasis immunology
Signal Transduction
T-Lymphocytes, Helper-Inducer immunology
B-Lymphocytes physiology
CD4-Positive T-Lymphocytes immunology
Down-Regulation
Granuloma pathology
Receptors, Fc physiology
Schistosomiasis pathology
Subjects
Details
- Language :
- English
- ISSN :
- 0022-1007
- Volume :
- 187
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- The Journal of experimental medicine
- Publication Type :
- Academic Journal
- Accession number :
- 9463412
- Full Text :
- https://doi.org/10.1084/jem.187.4.619