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Effects of NKH477, a forskolin derivative, and dibutyryl-cyclic AMP on adrenal catecholamine release in response to splanchnic nerve stimulation, acetylcholine, DMPP and muscarine in anesthetized dogs.
- Source :
-
Fundamental & clinical pharmacology [Fundam Clin Pharmacol] 1997; Vol. 11 (6), pp. 512-8. - Publication Year :
- 1997
-
Abstract
- The effects of NKH477, a water-soluble forskolin derivative, and dibutyryl-cyclic adenosine monophosphate (dbcAMP) on the release of adrenal catecholamines (CAs) in response to splanchnic nerve stimulation (SNS), acetylcholine (ACh), the nicotinic receptor stimulant 1,1-dimethyl-4-phenyl-piperazinium iodide (DMPP) and muscarine were examined in anesthetized dogs. NKH477, dbcAMP and the cholinergic agonists were infused and injected, respectively, into the adrenal gland intra-arterially. SNS (3 Hz) or injections of ACh (3 micrograms), DMPP (2 micrograms) and muscarine (2 micrograms) produced increases in CA output determined from adrenal venous blood. Both NKH477 infusion (0.3, 1 and 3 micrograms/min) and dbcAMP infusion (0.1, 0.3 and 1 mg/min) caused dose-dependent enhancement of the SNS-, ACh- and DMPP-induced increases in CA output, whereas they failed to affect the muscarine-induced increases in CA output. Neither NKH477 nor dbcAMP affected basal CA output. Cyclic AMP (cAMP) overflow determined from adrenal venous blood increased during NKH477 infusion. These results indicate that NKH477 and dbcAMP have facilitatory effects on adrenal CA release mediated by nicotinic receptors, but not by muscarinic receptors in the dog, and suggest the selective action of cAMP on nicotinic mechanism.
- Subjects :
- Acetylcholine pharmacology
Adrenal Glands metabolism
Animals
Bucladesine administration & dosage
Colforsin administration & dosage
Colforsin pharmacology
Dimethylphenylpiperazinium Iodide pharmacology
Dogs
Female
Infusions, Intra-Arterial
Injections, Intra-Arterial
Male
Muscarine pharmacology
Muscarinic Agonists pharmacology
Receptors, Nicotinic drug effects
Splanchnic Nerves physiology
Vasodilator Agents administration & dosage
Adrenal Glands drug effects
Bucladesine pharmacology
Catecholamines blood
Colforsin analogs & derivatives
Vasodilator Agents pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0767-3981
- Volume :
- 11
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Fundamental & clinical pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 9444518
- Full Text :
- https://doi.org/10.1111/j.1472-8206.1997.tb00855.x