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The differential transforming activities of Tal1 oncoproteins.
- Source :
-
Biochemistry and molecular biology international [Biochem Mol Biol Int] 1997 Dec; Vol. 43 (6), pp. 1157-61. - Publication Year :
- 1997
-
Abstract
- TAL1 (Or SCL) oncogene produces both full-length pp42 and truncated pp22 phosphoproteins in T-cell acute lymphoblastic leukemia cells. To investigate the transforming properties of these two oncoproteins, permanent transfected NIH3T3 cell lines were generated that constitutively express either pp42 or pp22. Both cell lines exhibited similar morphology as parental NIH3T3 cells. However, they showed differential anchorage independent growth in soft-agar. The clonogenicity of pp22 expressing cells was ten folds higher than that of pp42 expressing cells. This result might implicate the differential transformation potential of the two Tal1 oncoproteins.
- Subjects :
- 3T3 Cells cytology
3T3 Cells drug effects
Animals
Basic Helix-Loop-Helix Transcription Factors
Cell Adhesion drug effects
Cell Division drug effects
DNA-Binding Proteins genetics
Mice
T-Cell Acute Lymphocytic Leukemia Protein 1
Transfection
Cell Transformation, Neoplastic
DNA-Binding Proteins physiology
Proto-Oncogene Proteins
Transcription Factors
Subjects
Details
- Language :
- English
- ISSN :
- 1039-9712
- Volume :
- 43
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Biochemistry and molecular biology international
- Publication Type :
- Academic Journal
- Accession number :
- 9442912
- Full Text :
- https://doi.org/10.1080/15216549700204991