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Effects of gastrin-releasing peptide (GRP) on the mechanical activity of the human ileocaecal region in vitro.
- Source :
-
Neurogastroenterology and motility [Neurogastroenterol Motil] 1997 Dec; Vol. 9 (4), pp. 265-70. - Publication Year :
- 1997
-
Abstract
- Mechanical activity was recorded in muscle preparations isolated from the human ileocaecal region. Gastrin-releasing peptide (GRP, 10(-9)-10(-7) mol L-1) produced two types of response in the different muscle layers. Longitudinally cut strips showed a concentration-dependent increase in the rhythmic activity, whereas the circularly orientated layers generally reacted with a small decrease in tone. These effects could not be influenced by blockade of adrenergic or cholinergic receptors or nerve blockade with tetrodotoxin (TTX). Application of pentagastrin did not mimic the action of GRP. These findings suggest a direct action of GRP on smooth muscle via distinct receptors which have already been demonstrated to exist in human gastrointestinal tract. The opposite effects on circular and longitudinal strips might indicate a modulatory role of GRP in the control of ileocolonic transit.
- Subjects :
- Cecum innervation
Cecum physiology
Humans
Ileocecal Valve innervation
Ileocecal Valve physiology
Ileum innervation
Ileum physiology
In Vitro Techniques
Muscle Contraction drug effects
Muscle, Smooth innervation
Muscle, Smooth physiology
Pentagastrin pharmacology
Receptors, Immunologic physiology
Tetrodotoxin pharmacology
Cecum drug effects
Gastrin-Releasing Peptide pharmacology
Ileocecal Valve drug effects
Ileum drug effects
Muscle, Smooth drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1350-1925
- Volume :
- 9
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Neurogastroenterology and motility
- Publication Type :
- Academic Journal
- Accession number :
- 9430795
- Full Text :
- https://doi.org/10.1046/j.1365-2982.1997.d01-59.x