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Effects of raloxifene hydrochloride on the endometrium of postmenopausal women.
- Source :
-
American journal of obstetrics and gynecology [Am J Obstet Gynecol] 1997 Dec; Vol. 177 (6), pp. 1458-64. - Publication Year :
- 1997
-
Abstract
- Objective: We evaluated subtle endometrial morphologic changes in postmenopausal women assigned to placebo, raloxifene hydrochloride 200 or 600 mg/day, or conjugated estrogens (Premarin 0.625 mg/day) according to a new estrogenicity scoring system. Raloxifene, a new selective estrogen receptor modulator, was not expected to stimulate the endometrium.<br />Study Design: Baseline and end point endometrial biopsies were performed during this double-blind, placebo-controlled 8-week study. A scoring system that was based on standard glandular and stromal morphologic criteria was used to quantitate estrogen-induced effects. Baseline, end point, and baseline-to-end point changes were analyzed for treatment differences.<br />Results: Treatment groups were similar at baseline with most women showing no estrogenic effects. At end point, statistically significant moderate and marked estrogenic effects were noted in 77% of estrogen-treated women versus 15% of placebo-treated women versus 0% of raloxifene-treated women.<br />Conclusions: As expected, estrogen treatment stimulated postmenopausal endometrium. In contrast, raloxifene did not induce histopathologic evidence of endometrial stimulation in healthy postmenopausal women.
- Subjects :
- Biopsy
Double-Blind Method
Endometrium pathology
Estradiol blood
Estrogens, Conjugated (USP) therapeutic use
Female
Humans
Middle Aged
Postmenopause blood
Raloxifene Hydrochloride
Stimulation, Chemical
Endometrium drug effects
Estrogen Antagonists therapeutic use
Piperidines therapeutic use
Postmenopause physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0002-9378
- Volume :
- 177
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- American journal of obstetrics and gynecology
- Publication Type :
- Academic Journal
- Accession number :
- 9423751
- Full Text :
- https://doi.org/10.1016/s0002-9378(97)70091-7