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Testicular toxicity assessment of Andrographis paniculata dried extract in rats.
- Source :
-
Journal of ethnopharmacology [J Ethnopharmacol] 1997 Nov; Vol. 58 (3), pp. 219-24. - Publication Year :
- 1997
-
Abstract
- The possible testicular toxicity of Andrographis paniculata, Nees (Acanthaceae) standardized dried extract was evaluated in male Sprague Dawley rats for 60 days. No testicular toxicity was found with the treatment of 20, 200 and 1000 mg/kg during 60 days as evaluated by reproductive organ weight, testicular histology, ultrastructural analysis of Leydig cells and testosterone levels after 60 days of treatment. It is concluded that Andrographis paniculata dried extract did not produce subchronic testicular toxicity effect in male rats.
- Subjects :
- Animals
Leydig Cells drug effects
Leydig Cells ultrastructure
Male
Microscopy, Electron
Organ Size drug effects
Plant Extracts toxicity
Rats
Rats, Sprague-Dawley
Testicular Diseases pathology
Testis pathology
Testis ultrastructure
Testosterone blood
Plants, Medicinal chemistry
Testicular Diseases chemically induced
Subjects
Details
- Language :
- English
- ISSN :
- 0378-8741
- Volume :
- 58
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of ethnopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 9421258
- Full Text :
- https://doi.org/10.1016/s0378-8741(97)00099-8