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Effect of magnetic resonance exposure combined with gadopentetate dimeglumine on chromosomes in animal specimens.
- Source :
-
Academic radiology [Acad Radiol] 1995 Jun; Vol. 2 (6), pp. 492-6. - Publication Year :
- 1995
-
Abstract
- Rationale and Objectives: We tested for the presence of a form of unstable chromosomal damage--anaphase bridges--that might result from the combined exposure to gadopentetate dimeglumine and magnetic resonance (MR) imaging in rats.<br />Methods: Fifty-four male Sprague-Dawley rats, along with appropriate controls, were exposed either to MR imaging alone, gadopentetate dimeglumine alone, or a combination of the two. After exposure, partial hepatectomies were performed to induce a vigorous mitotic response in the regenerating liver stump. Twenty-eight to 30 hr after partial hepatectomy, tissue specimens from regenerating liver were removed and analyzed microscopically for the presence of anaphase bridges.<br />Results: No anaphase bridges were detected in any of the animals, including those exposed to gadopentetate dimeglumine and MR imaging.<br />Conclusion: Using anaphase bridge formation as an indicator, exposure to MR imaging alone, gadopentetate dimeglumine alone, or a combination of the two under the conditions used in this experiment did not cause detectable unstable chromosomal damage.
- Subjects :
- Anaphase drug effects
Anaphase genetics
Anaphase radiation effects
Animals
Cell Count drug effects
Cell Count radiation effects
DNA Damage drug effects
DNA Damage radiation effects
Hepatectomy
Liver Regeneration drug effects
Liver Regeneration radiation effects
Male
Rats
Rats, Sprague-Dawley
Safety
Chromosome Aberrations
Chromosomes drug effects
Chromosomes radiation effects
Contrast Media adverse effects
Gadolinium DTPA adverse effects
Liver drug effects
Liver radiation effects
Magnetic Resonance Imaging adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1076-6332
- Volume :
- 2
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Academic radiology
- Publication Type :
- Academic Journal
- Accession number :
- 9419596
- Full Text :
- https://doi.org/10.1016/s1076-6332(05)80405-2