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Antibody response to the 60-kDa chlamydial heat-shock protein is associated with scarring trachoma.
- Source :
-
The Journal of infectious diseases [J Infect Dis] 1998 Jan; Vol. 177 (1), pp. 256-9. - Publication Year :
- 1998
-
Abstract
- To determine if serum antibody response to the 60-kDa chlamydial heat-shock protein (Chsp60) was associated with scarring trachoma, responses to Chlamydia trachomatis and to Chsp60 from 148 Gambian subjects with trachomatous scarring and from 148 controls without clinical evidence of disease from trachoma-endemic communities were characterized. Chsp60 response was found in 32% of cases and 16% of controls (P < .001). Although C. trachomatis titer was also higher in cases than controls, the prevalence of Chsp60 response between the 2 groups remained significantly different after stratifying for C. trachomatis titer (weighted odds ratio [OR] = 2.1, P = .02). Chsp60 response and C. trachomatis serovar A titer of > or =128 were independently associated with scarring trachoma. The presence of HLA class II allele DRB1*0701 was positively correlated with Chsp60 response (OR = 2.6, P = .02), and DQB1*0301 and DQB1*0501 were negatively associated (OR = 0.42, P < .001; OR = 0.55, P = .46, respectively).
- Subjects :
- Age Factors
Antibodies, Bacterial immunology
Chlamydia trachomatis pathogenicity
Chlamydophila pneumoniae immunology
Gambia epidemiology
Histocompatibility Antigens Class II analysis
Histocompatibility Testing
Humans
Multivariate Analysis
Odds Ratio
Prevalence
Seroepidemiologic Studies
Sex Factors
Trachoma epidemiology
Trachoma genetics
Antibodies, Bacterial analysis
Chaperonin 60 immunology
Chlamydia trachomatis immunology
Trachoma immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0022-1899
- Volume :
- 177
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- The Journal of infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 9419202
- Full Text :
- https://doi.org/10.1086/517367