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The effect of valaciclovir on cytomegalovirus viremia and viruria detected by polymerase chain reaction in patients with advanced human immunodeficiency virus disease. AIDS Clinical Trials Group Protocol 204/Glaxo Wellcome 123-014 International CMV Prophylaxis Study Group.
- Source :
-
The Journal of infectious diseases [J Infect Dis] 1998 Jan; Vol. 177 (1), pp. 57-64. - Publication Year :
- 1998
-
Abstract
- Samples of blood and urine were collected at baseline, week 4, and week 8 and then every 8 weeks from 310 patients entering a controlled trial of prophylaxis with valaciclovir versus acyclovir. Samples were tested under code by polymerase chain reaction (PCR) in one laboratory. The median number of samples collected from each patient was 5 for blood (range, 0-15) and 5 for urine (range, 0-15). Both baseline PCR viremia and PCR viruria were significantly associated with future cytomegalovirus (CMV) disease (P = .002 and P = .02, respectively). The greatest effect of valaciclovir on CMV disease was seen in patients who were PCR-positive in blood at baseline (P = .002), although a significant effect was also seen in those who were PCR-negative in urine (P = .02). Thus, PCR viremia provides prognostic information about CMV disease in AIDS patients, and valaciclovir showed activity as both a preemptive and prophylactic agent.
- Subjects :
- AIDS-Related Opportunistic Infections diagnosis
AIDS-Related Opportunistic Infections virology
Acyclovir administration & dosage
Acyclovir therapeutic use
Adult
Antiviral Agents administration & dosage
CD4 Lymphocyte Count
Cytomegalovirus Infections diagnosis
Cytomegalovirus Infections urine
DNA, Viral isolation & purification
Double-Blind Method
Female
Humans
Male
Multivariate Analysis
Polymerase Chain Reaction
Prognosis
Valacyclovir
Valine administration & dosage
Valine therapeutic use
Viremia diagnosis
Viremia drug therapy
AIDS-Related Opportunistic Infections drug therapy
Acyclovir analogs & derivatives
Antiviral Agents therapeutic use
Cytomegalovirus drug effects
Cytomegalovirus isolation & purification
Cytomegalovirus Infections drug therapy
Valine analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 0022-1899
- Volume :
- 177
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- The Journal of infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 9419170
- Full Text :
- https://doi.org/10.1086/513806