Characterisation of the rat and mouse homologues of gC1qBP, a 33 kDa glycoprotein that binds to the globular 'heads' of C1q.

Authors :: Lynch NJ
Reid KB
van den Berg RH
Daha MR
Leigh LA
Ghebrehiwet B
Lim WB
Schwaeble WJ
Source :: FEBS letters [FEBS Lett] 1997 Nov 24; Vol. 418 (1-2), pp. 111-4.
Publication Year :: 1997
Abstract: gC1qBP is a 33 kDa glycoprotein that binds to the globular 'heads' of C1q. We have cloned cDNAs encoding the rat and mouse homologues of gC1qBP. Comparison of the cDNA-derived amino acid sequences of gC1qBP reveals that either of the rodent sequences is 89.9% identical to the reported human sequence. Recombinant rat gC1qBP binds avidly to human C1q. gC1qBP mRNA is abundantly expressed in every rat and mouse tissue analysed. Rat mesangial cells synthesise gC1qBP, but do not express gC1qBP on the cell surface. In rat serum, gC1qBP is present at low levels.

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