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A synthesis of 7alpha-hydroxyandrost-4-ene-3,17-dione.

Authors :
Hossain AM
Kirk DN
Mitra G
Source :
Steroids [Steroids] 1976 May; Vol. 27 (5), pp. 603-8.
Publication Year :
1976

Abstract

The first convenient chemical synthesis of 7alpha-hydroxyandrost-4-ene-3,17-dione is reported. Androsta-4,6-diene3, 17-dione was converted into its 6alpha, 7alpha-epoxy-derivative; reduction of the epoxide with aluminum amalgam gave 7alpha-hydroxyandrost-4-ene-3,17-dione. This reducing agent is more efficient than chromous acetate for the purpose.

Subjects

Subjects :
Androstenedione chemical synthesis
Hydroxysteroids chemical synthesis
Methods
Oxidation-Reduction
Androstenedione analogs & derivatives

Details

Language :
English
ISSN :
0039-128X
Volume :
27
Issue :
5
Database :
MEDLINE
Journal :
Steroids
Publication Type :
Academic Journal
Accession number :
941180
Full Text :
https://doi.org/10.1016/s0039-128x(76)90096-9
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