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Effects of nitric oxide synthase inhibition on the hemodynamic changes in hyperdynamic endotoxemia.
- Source :
-
Acta chirurgica Hungarica [Acta Chir Hung] 1997; Vol. 36 (1-4), pp. 393-4. - Publication Year :
- 1997
-
Abstract
- In this study we compared the circulatory effects of the arginine analogue non-specific nitric oxide synthase (NOS) inhibitor N omega-nitro-L-arginine (NNA), and the specific inducible NOS (iNOS) inhibitor S-methylisothiourea (SMT) and S-(2-aminoethyl)-isothiourea (AEST) in a hyperdynamic endotoxemic dog model. Mean arterial pressure (MAP), cardiac output (CO), and myocardial contractility (MC) were measured. A hyperdynamic circulatory response was elicited with a 2-h infusion of a total dose of 5.3 micrograms/kg E. coli endotoxin (ETX). NOS inhibitory treatment (2 mg/kg) was administrated from the 45th min of endotoxemia. ETX induced a hyperdynamic circulatory response, and a significant myocardial depression. NNA induced a prolonged, SMT a transient increase in MC, both drugs elevated MAP, but decreased CO. AEST significantly prolonged the elevation in CO, but did not affect MAP. Selective inhibition of the iNOS may be a beneficial in sepsis.
- Subjects :
- Animals
Blood Circulation drug effects
Blood Pressure drug effects
Cardiac Output drug effects
Disease Models, Animal
Dogs
Endotoxemia drug therapy
Endotoxins administration & dosage
Endotoxins adverse effects
Escherichia coli
Escherichia coli Infections drug therapy
Isothiuronium analogs & derivatives
Isothiuronium pharmacology
Myocardial Contraction drug effects
Nitroarginine pharmacology
Ventricular Function, Left drug effects
Ventricular Pressure drug effects
Endotoxemia physiopathology
Enzyme Inhibitors pharmacology
Escherichia coli Infections physiopathology
Hemodynamics drug effects
Nitric Oxide Synthase antagonists & inhibitors
beta-Aminoethyl Isothiourea pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0231-4614
- Volume :
- 36
- Issue :
- 1-4
- Database :
- MEDLINE
- Journal :
- Acta chirurgica Hungarica
- Publication Type :
- Academic Journal
- Accession number :
- 9408415