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Proton magnetic resonance spectroscopy in Parkinson's disease and atypical parkinsonian disorders.
- Source :
-
Movement disorders : official journal of the Movement Disorder Society [Mov Disord] 1997 Nov; Vol. 12 (6), pp. 903-9. - Publication Year :
- 1997
-
Abstract
- Proton magnetic resonance spectroscopy (1H-MRS), localized to the lentiform nucleus, was carried out in 12 patients with idiopathic Parkinson's disease (IPD), seven patients with multiple-system atrophy (MSA), seven patients with progressive supranuclear palsy (PSP), and 10 healthy age-matched controls. The study assessed the level of N-acetylaspartate (NAA), creatine-phosphocreatine (Cr), and choline (Cho) in the putamen and globus pallidus of these patients. NAA/Cho and NAA/Cr ratios were significantly reduced in MSA and PSP patients. No significant difference was found between IPD patients and controls. These results suggest an NAA deficit, due to neuronal loss, in the lentiform nucleus of MSA and PSP patients. 1H-MRS is a noninvasive technique that can provide useful information regarding striatal neuronal loss in basal ganglia of patients with atypical parkinsonian disorders and represents a potential tool for diagnosing these disorders.
- Subjects :
- Aged
Antiparkinson Agents therapeutic use
Aspartic Acid metabolism
Atrophy pathology
Choline metabolism
Corpus Striatum metabolism
Creatinine metabolism
Female
Globus Pallidus metabolism
Globus Pallidus pathology
Humans
Levodopa therapeutic use
Middle Aged
Parkinson Disease drug therapy
Phosphocreatine metabolism
Putamen metabolism
Putamen pathology
Supranuclear Palsy, Progressive pathology
Cerebral Cortex pathology
Magnetic Resonance Spectroscopy
Parkinson Disease pathology
Parkinson Disease, Secondary pathology
Protons
Subjects
Details
- Language :
- English
- ISSN :
- 0885-3185
- Volume :
- 12
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Movement disorders : official journal of the Movement Disorder Society
- Publication Type :
- Academic Journal
- Accession number :
- 9399213
- Full Text :
- https://doi.org/10.1002/mds.870120611