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A fresh look at the molecular pharmacology of plasminogen activators: from theory to test tube to clinical outcomes.
- Source :
-
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists [Am J Health Syst Pharm] 1997 Nov 15; Vol. 54 Suppl 1, pp. S17-22. - Publication Year :
- 1997
-
Abstract
- The molecular pharmacology of plasminogen activators and its implications for thrombolytic therapy are discussed. The benefits of coronary thrombolysis were first demonstrated with intracoronary and i.v. streptokinase. Tissue plasminogen activator (t-PA) or recombinant t-PA (alteplase) proved to be superior to streptokinase with respect to speed of reperfusion and reperfusion efficacy. Since alteplase neither lessened the risk of bleeding found with streptokinase nor generated Thrombolysis in Myocardial Infarction (TIMI) grade 3 flow rates above about 50%, the quest for faster-acting, safer, and more effective thrombolytic agents has continued. The ideal agent would be highly efficient at converting plasminogen to plasmin, have an intermediate half-life, have a low affinity for fibrin, and be of reasonable cost. Genetic engineering of the wild-type t-PA molecule resulted in reteplase, which has a longer half-life than alteplase and may be superior in terms of lytic activity, myocardial salvage, and survival. Also under investigation are TNK-t-PA and n-PA, which have longer half-lives and, in animal models, seem to produce more rapid and complete thrombolysis, at less risk of intracranial bleeding, than alteplase. The risk of intracranial bleeding remains a problem with all thrombolytics; the risk versus the benefit will have to be assessed in large randomized trials. An understanding of the functions of various regions of the t-PA molecule has led to genetic engineering of new and promising plasminogen activators.
- Subjects :
- Animals
Fibrinolysin metabolism
Humans
Myocardial Infarction drug therapy
Plasminogen metabolism
Plasminogen Activators therapeutic use
Recombinant Proteins pharmacology
Recombinant Proteins therapeutic use
Streptokinase pharmacology
Streptokinase therapeutic use
Tissue Plasminogen Activator pharmacology
Tissue Plasminogen Activator therapeutic use
Plasminogen Activators pharmacology
Thrombolytic Therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1079-2082
- Volume :
- 54 Suppl 1
- Database :
- MEDLINE
- Journal :
- American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists
- Publication Type :
- Academic Journal
- Accession number :
- 9397233
- Full Text :
- https://doi.org/10.1093/ajhp/54.suppl_1.S17