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Acute immune polyneuropathies: correlations of serum antibodies to Campylobacter jejuni and Helicobacter pylori with anti-GM1 antibodies and clinical patterns of disease.
- Source :
-
The Journal of infectious diseases [J Infect Dis] 1997 Dec; Vol. 176 Suppl 2, pp. S154-6. - Publication Year :
- 1997
-
Abstract
- Antecedent Campylobacter jejuni infection, detected by serologic tests, has been implicated in some acute immune polyneuropathies (AIP). Antibodies to Helicobacter pylori, C. jejuni, and GM1 ganglioside were measured in sera from 35 Chinese patients with AIP. Anti-GM1 antibodies were found in 54% of C. jejuni-seropositive, H. pylori-seronegative patients. In contrast, anti-GM1 antibodies were rare in sera that were either seropositive for both C. jejuni and H. pylori (P = .04) or seronegative for C. jejuni (P = .01). Motor axonal AIP was more common in the C. jejuni-seropositive, H. pylori-seronegative patients (82%) than in the bacterial antibody-negative group (38%). It was concluded that in AIP patients, C. jejuni-positive sera may be polyreactive, in that it may also react with H. pylori. In this situation, the specificity for either infection requires further validation. In contrast, sera with specific C. jejuni seropositivity are associated with both motor axonal AIP and selective serum IgG anti-GM1 antibodies.
- Subjects :
- Antibody Specificity
Campylobacter Infections complications
Campylobacter Infections immunology
China epidemiology
Helicobacter Infections complications
Helicobacter Infections immunology
Humans
Immunoglobulin A blood
Immunoglobulin G blood
Immunoglobulin M blood
Polyneuropathies epidemiology
Polyradiculoneuropathy epidemiology
Seroepidemiologic Studies
Antibodies, Bacterial blood
Autoantibodies blood
Campylobacter jejuni immunology
G(M1) Ganglioside immunology
Helicobacter pylori immunology
Polyneuropathies immunology
Polyradiculoneuropathy immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0022-1899
- Volume :
- 176 Suppl 2
- Database :
- MEDLINE
- Journal :
- The Journal of infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 9396701
- Full Text :
- https://doi.org/10.1086/513784