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Interrelationships among quantity of human cytomegalovirus (HCMV) DNA in blood, donor-recipient serostatus, and administration of methylprednisolone as risk factors for HCMV disease following liver transplantation.
- Source :
-
The Journal of infectious diseases [J Infect Dis] 1997 Dec; Vol. 176 (6), pp. 1484-90. - Publication Year :
- 1997
-
Abstract
- Longitudinal analysis of 162 liver transplant recipients identified 51 patients who were viremic. Virus load was determined in 47 of these patients using quantitative-competitive polymerase chain reaction. Peak virus load was significantly higher in 20 symptomatic patients than 27 asymptomatic patients (P < .0001). Elevated virus load, donor seropositivity, and total methylprednisolone dosage were risk factors for human cytomegalovirus (HCMV) disease (odds ratio [OR], 2.22/0.25 log10 increase in virus load, P = .001; OR, 4.11, P = .05; OR, 1.30/1-g increment in methylprednisolone, P = .01). Methylprednisolone and virus load were independent risk factors in a multivariate analysis (OR, 2.70/1-g increase, P = .003; OR, 1.61/0.25 log10 increase, P = .03, respectively). Virus loads of 10(4.75)-10(5.25) genomes/mL of blood were associated with an increased disease probability; the latter was shifted to lower virus loads with increasing quantities of methylprednisolone. These data illustrate the central role of virus load in HCMV pathogenesis.
- Subjects :
- Adolescent
Adult
Aged
Antibodies, Viral blood
Antibodies, Viral immunology
Child
Cytomegalovirus genetics
Cytomegalovirus immunology
Cytomegalovirus Infections virology
DNA, Viral genetics
Humans
Immunosuppressive Agents administration & dosage
Immunosuppressive Agents therapeutic use
Longitudinal Studies
Methylprednisolone administration & dosage
Methylprednisolone therapeutic use
Middle Aged
Multivariate Analysis
Polymerase Chain Reaction
Prospective Studies
Risk Factors
Tissue Donors
Viral Load
Cytomegalovirus isolation & purification
Cytomegalovirus Infections etiology
DNA, Viral blood
Immunosuppressive Agents adverse effects
Liver Transplantation adverse effects
Methylprednisolone adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 0022-1899
- Volume :
- 176
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- The Journal of infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 9395358
- Full Text :
- https://doi.org/10.1086/514145