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Compartment-ablation studies of GLUT4 distribution in adipocytes: evidence for multiple intracellular pools.
- Source :
-
Biochemical Society transactions [Biochem Soc Trans] 1997 Aug; Vol. 25 (3), pp. 974-7. - Publication Year :
- 1997
-
Abstract
- The available data suggest that GLUT4 does populate the recycling endosomal system to some extent, but that a large proportion of the intracellular GLUT4 resides in a compartment that is devoid of transferrin receptors and may have properties more akin to specialized secretory vesicles. The study of the nature and biogenesis of this compartment will provide important insight into the mechanism by which insulin stimulates glucose transport. Further study of the role of the synaptobrevins in these distinct subcellular compartments will probably shed further light on the mechanism by which insulin stimulates GLUT4 translocation.
- Subjects :
- Adipocytes ultrastructure
Animals
Cytoplasmic Granules metabolism
Cytoplasmic Granules ultrastructure
Endosomes metabolism
Endosomes ultrastructure
Glucose Transporter Type 4
Membrane Proteins analysis
Microscopy, Immunoelectron
Monosaccharide Transport Proteins analysis
Nerve Tissue Proteins analysis
Organelles ultrastructure
R-SNARE Proteins
Synaptic Vesicles metabolism
Adipocytes metabolism
Monosaccharide Transport Proteins metabolism
Muscle Proteins
Organelles metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0300-5127
- Volume :
- 25
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Biochemical Society transactions
- Publication Type :
- Academic Journal
- Accession number :
- 9388584
- Full Text :
- https://doi.org/10.1042/bst0250974