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Encoding and selective activation of "metabolic memories" in the rat.
- Source :
-
Behavioral neuroscience [Behav Neurosci] 1997 Oct; Vol. 111 (5), pp. 1014-30. - Publication Year :
- 1997
-
Abstract
- Experiment 1 used Pavlovian conditioning procedures to show that rats formed distinct memorial representations of 2 (peanut oil and sucrose pellets) unconditioned stimuli (USs) that could be activated by 2 different conditioned stimuli (CSs). After training in Experiment 2, rats injected with the lipid antimetabolite Na-2-mercaptoacetate (MA) responded more to the CS for oil than to the CS for sucrose. This pattern was not shown by rats that received isotonic saline or systemic 2-deoxy-d-glucose (a glucose antimetabolite). By contrast, intracerebroventricular infusion of the glucose antimetabolite 5-thioglucose selectively promoted responding to the CS for sucrose (Experiment 4). Thus, lipoprivic and glucoprivic treatments selectively promoted the activation of the memories of fat and carbohydrate USs, respectively. In Experiment 3, the capacity of MA to augment responding to a CS for oil was abolished for rats that received subdiaphragmatic vagal deafferentation. This indicates that the capacity of lipoprivic signals to selectively activate the representations of fat USs may depend on vagal afferent fibers.
- Subjects :
- Animals
Antimetabolites pharmacology
Association Learning drug effects
Association Learning physiology
Avoidance Learning drug effects
Avoidance Learning physiology
Blood Glucose metabolism
Brain drug effects
Conditioning, Classical drug effects
Deoxyglucose pharmacology
Energy Metabolism drug effects
Fatty Acids, Nonesterified blood
Feeding Behavior drug effects
Food Preferences drug effects
Food Preferences physiology
Injections, Intraventricular
Male
Mental Recall drug effects
Motivation
Peanut Oil
Plant Oils administration & dosage
Rats
Rats, Sprague-Dawley
Sucrose administration & dosage
Taste drug effects
Taste physiology
Thioglycolates pharmacology
Brain physiology
Conditioning, Classical physiology
Energy Metabolism physiology
Feeding Behavior physiology
Mental Recall physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0735-7044
- Volume :
- 111
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Behavioral neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 9383521
- Full Text :
- https://doi.org/10.1037//0735-7044.111.5.1014