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[A new micromethod in medicine: capillary electrophoresis].

Authors :
Demel U
Source :
Wiener medizinische Wochenschrift (1946) [Wien Med Wochenschr] 1997; Vol. 147 (14), pp. 336-8.
Publication Year :
1997

Abstract

This is an original contribution on the first CZE in Austrian public and university hospitals. We are describing now the first results obtained with a new micro-method, namely CZE. Proteins are separated in microliter amounts by using 10,000 V and analyzed in a laser beam. 50 counts can be worked out per hour and immunoelectrophoresis replaced by subtraction CE. Dysproteinemias, double albuminemias, modifications of the haptoglobins, alpha-2 macroglobulin, transferin, complement system and the immunoglobulins can easily be detected and monoclonality revealed. No support except the capillary with buffer is necessary, no staining procedure required. The new system is rapid, reliable, cheap and reproducible, and allows us to replace more extensive forms of protein diagnosis such as the traditional electrophoresis and the immunoelectrophoresis or the immunoblotting.

Details

Language :
German
ISSN :
0043-5341
Volume :
147
Issue :
14
Database :
MEDLINE
Journal :
Wiener medizinische Wochenschrift (1946)
Publication Type :
Academic Journal
Accession number :
9381728