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Antimicrobial and genotoxic activities of N-hydroxyalkyl-1, 2-benzisothiazol-3(2H)-one carbamic esters.
- Source :
-
Farmaco (Societa chimica italiana : 1989) [Farmaco] 1997 Jun-Jul; Vol. 52 (6-7), pp. 359-66. - Publication Year :
- 1997
-
Abstract
- N-Hydroxyethyl- and N-hydroxypropyl-1,2-benzisothiazol-3(2H)-one carbamic esters were prepared in order to test their activity against representative bacterial and fungal strains. The obtained results were compared with those reported for parent alcohols and some interesting considerations were drawn. None of the studied derivatives possess genotoxic activity in the Bacillus subtilis rec-assay and Salmonella-microsome test.
- Subjects :
- Anti-Bacterial Agents
Anti-Infective Agents chemical synthesis
Antifungal Agents chemical synthesis
Bacillus subtilis drug effects
Bacillus subtilis genetics
Candida albicans drug effects
Clostridium perfringens drug effects
DNA, Bacterial drug effects
Molecular Structure
Mutagenicity Tests
Mutagens chemical synthesis
Salmonella typhimurium drug effects
Salmonella typhimurium genetics
Staphylococcus drug effects
Staphylococcus aureus drug effects
Trichophyton drug effects
Anti-Infective Agents pharmacology
Antifungal Agents pharmacology
Carbamates chemical synthesis
Carbamates pharmacology
Gram-Positive Bacteria drug effects
Mutagens pharmacology
Thiazoles chemical synthesis
Thiazoles pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0014-827X
- Volume :
- 52
- Issue :
- 6-7
- Database :
- MEDLINE
- Journal :
- Farmaco (Societa chimica italiana : 1989)
- Publication Type :
- Academic Journal
- Accession number :
- 9372586