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High prevalence of vitamin D deficiency and reduced bone mass in Parkinson's disease.
- Source :
-
Neurology [Neurology] 1997 Nov; Vol. 49 (5), pp. 1273-8. - Publication Year :
- 1997
-
Abstract
- Despite excessive hip fractures in patients with Parkinson's disease (PD), little is known about bone changes in these patients. We measured bone mineral density (BMD; Z scores) in PD patients and analyzed its relation to serum biochemical indices and sunlight exposure. We measured BMD in 71 patients in the second metacarpals and divided the patients into two groups according to functional independence; group 1, Hoehn and Yahr stages 1 and 2; and group 2, stages 3 to 5. In four of 20 patients in group 1 (20%), the Z score was less than -1.0, indicating osteopenia. In 51 patients in group 2, 31 (61%) had a Z score less than -1.0. The group 1 patients showed a normal mean serum level of 25-hydroxyvitamin D (25-OHD; 21.7 ng/ml), while most group 2 patients were in a deficiency range (group mean 8.9 ng/ml). Many group 2 patients were sunlight deprived. Both groups had elevated serum ionized calcium levels correlating positively with Hoehn and Yahr stage and markedly depressed serum 1,25-dihydroxyvitamin D (1,25-[OH]2D) concentrations, indicating that immobilization-induced hypercalcemia had inhibited 1,25-[OH]2D production. Z scores correlated positively with 25-OHD levels and negatively with parathyroid hormone concentration and Hoehn and Yahr stage. Vitamin D deficiency due to sunlight deprivation and hypercalcemia induces compensatory hyperparathyroidism, which contributes to reduced BMD in PD patients, particularly those who are functionally dependent. Low BMD increases risk of hip fractures in patients with PD but may be improved by vitamin D supplementation.
- Subjects :
- Absorptiometry, Photon
Age Distribution
Aged
Aged, 80 and over
Bone Density
Bone Diseases, Metabolic complications
Bone Diseases, Metabolic metabolism
Calcium metabolism
Female
Hip Fractures etiology
Hip Fractures prevention & control
Humans
Male
Metacarpus metabolism
Middle Aged
Parathyroid Hormone blood
Parkinson Disease complications
Prevalence
Vitamin D analogs & derivatives
Vitamin D blood
Vitamin D Deficiency complications
Bone Diseases, Metabolic diagnosis
Bone Diseases, Metabolic epidemiology
Parkinson Disease epidemiology
Parkinson Disease metabolism
Vitamin D Deficiency epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 0028-3878
- Volume :
- 49
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Neurology
- Publication Type :
- Academic Journal
- Accession number :
- 9371907
- Full Text :
- https://doi.org/10.1212/wnl.49.5.1273