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The regional pattern of D4 gene expression in human brain.

Authors :
Mulcrone J
Kerwin RW
Source :
Neuroscience letters [Neurosci Lett] 1997 Oct 03; Vol. 234 (2-3), pp. 147-50.
Publication Year :
1997

Abstract

Using a competitive reverse transcription-polymerase chain reaction (RT-PCR) assay levels of D4 gene expression have been determined in 16 regions obtained from a single control brain. Relatively high levels of expression were detected in the prefrontal and temporolimbic structures whilst low levels were detected in striatal regions. This pattern correlates with the reported distribution of the D4 receptor.

Subjects

Subjects :
Gene Expression
Humans
Polymerase Chain Reaction methods
Transcription, Genetic
Brain metabolism
Brain Mapping methods
Receptors, Dopamine genetics

Details

Language :
English
ISSN :
0304-3940
Volume :
234
Issue :
2-3
Database :
MEDLINE
Journal :
Neuroscience letters
Publication Type :
Academic Journal
Accession number :
9364519
Full Text :
https://doi.org/10.1016/s0304-3940(97)00702-7
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