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Late pulmonary impairment following allogeneic bone marrow transplantation.
- Source :
-
European journal of medical research [Eur J Med Res] 1996 Apr 18; Vol. 1 (7), pp. 343-8. - Publication Year :
- 1996
-
Abstract
- The pulmonary function of 88 consecutive leukemic patients who had undergone allogeneic bone marrow transplantation (BMT) was studied beforehand, at 3 months, at 6 months, and annually thereafter until 5 years after grafting. The parameters for function which are indicative for obstructive and restrictive lung disease deteriorated in all patient groups during the first 3 to 6 months after BMT but partially recovered within one year. Long-term decline in lung function was similar in all patient groups, and neither the onset nor the magnitude of pulmonary dysfunction was related to the occurrence of pulmonary impairment within 6 months after grafting. Multivariate analysis was then employed to assess predictors for long-term pulmonary disease. Despite the obvious effect of chronic graft versus host disease on the course of lung function, it was in itself not a significant predictor of long-term pulmonary outcome. Rather, the conditioning regimen turned out to be indicative; compared with busulfan, fractionated total body irradiation was demonstrated to be clearly superior with a lower incidence of both restrictive and obstructive long-term lung impairment. Our data indicate a previously unknown long-term side effect of busulfan conditioning.
- Subjects :
- Adult
Bone Marrow Transplantation immunology
Drug Therapy, Combination
Female
Follow-Up Studies
Graft vs Host Disease prevention & control
Humans
Immunosuppressive Agents therapeutic use
Leukemia, Myelogenous, Chronic, BCR-ABL Positive therapy
Leukemia, Myeloid, Acute therapy
Lung Diseases diagnosis
Lung Diseases epidemiology
Lung Diseases, Obstructive diagnosis
Lung Diseases, Obstructive epidemiology
Male
Multivariate Analysis
Precursor Cell Lymphoblastic Leukemia-Lymphoma therapy
Respiratory Function Tests
Time Factors
Transplantation, Homologous
Bone Marrow Transplantation adverse effects
Lung Diseases etiology
Lung Diseases, Obstructive etiology
Postoperative Complications
Subjects
Details
- Language :
- English
- ISSN :
- 0949-2321
- Volume :
- 1
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- European journal of medical research
- Publication Type :
- Academic Journal
- Accession number :
- 9364037