6-Chloro-5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]-5-pyridyl]carbamoyl]- indoline (SB-242084): the first selective and brain penetrant 5-HT2C receptor antagonist.

Subjects

Subjects :

Aminopyridines chemistry
Aminopyridines pharmacokinetics
Animals
Cell Line
Cytochrome P-450 Enzyme Inhibitors
Enzyme Inhibitors pharmacology
Humans
Indoles chemistry
Indoles pharmacokinetics
Molecular Structure
Rats
Receptor, Serotonin, 5-HT2C
Serotonin Antagonists chemistry
Serotonin Antagonists pharmacokinetics
Aminopyridines pharmacology
Blood-Brain Barrier
Indoles pharmacology
Receptors, Serotonin drug effects
Serotonin Antagonists pharmacology

Details

Language :

English

ISSN :

0022-2623

Volume :

40

Issue :

22

Database :

MEDLINE

Journal :

Journal of medicinal chemistry

Publication Type :

Academic Journal

Accession number :

9357513

Full Text :

https://doi.org/10.1021/jm970424c