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Dose-dependent response of central dopaminergic systems to metoclopramide in mice.
- Source :
-
Indian journal of experimental biology [Indian J Exp Biol] 1997 Jun; Vol. 35 (6), pp. 618-22. - Publication Year :
- 1997
-
Abstract
- Metoclopramide (5 to 40 mg/kg, i.p.) induces catalepsy and antagonised apomorphine induced cage climbing behaviour in mice. This further indicate its postsynaptic striatal and mesolimbic D 2 dopamine (DA) receptor blocking activity. Metoclopramide at 1.25 and 2.5 mg/kg, i.p. induced stereotyped cage climbing behaviour in mice. Pretreatment with haloperidol and alpha-methyl-p-tyrosine significantly antagonised metoclopramide (1.25 and 2.5 mg/kg)-induced stereotyped cage climbing behaviour. Metoclopramide at these doses induces stereotyped cage climbing behaviour by releasing DA from the mesolimbic dopaminergic neurons with resultant activation of the postsynaptic mesolimbic D 2 DA receptors by the released DA. DA releasing action of metoclopramide (1.25 and 2.5 mg/kg, i.p.) and the subsequent induction of the stereotyped cage climbing behaviour by these doses of metoclopramide is explained on the basis of selective blockade of the presynaptic D 2 DA autoreceptors by these doses of metoclopramide.
Details
- Language :
- English
- ISSN :
- 0019-5189
- Volume :
- 35
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Indian journal of experimental biology
- Publication Type :
- Academic Journal
- Accession number :
- 9357166