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Comparison of organochlorine pesticide and polychlorinated biphenyl residues in human breast adipose tissue and serum.
- Source :
-
Journal of toxicology and environmental health [J Toxicol Environ Health] 1997 Nov; Vol. 52 (4), pp. 285-93. - Publication Year :
- 1997
-
Abstract
- The presence of organochlorine pesticides, such as p,p'-DDT[2,2-bis(p-chlorophenyl)-1,1,1-trichloroethanel, and of polychlorinated biphenyls (PCBs) in human serum and adipose tissue has been reported in many studies over the last four decades. Recently, debate has heightened concerning the link of these compounds to breast cancer. To clarify and resolve this issue, accurate analytical residue data must be obtained. Separation of the organochlorine pesticides from the PCBs in breast tissue is critical to obtaining valid residue data. Based on methods refined in the Analytical Laboratory at Colorado State University, accurate residue levels were established for nine individual PCB congeners and eight organochlorine pesticides. The breast adipose tissue method used was a modification of the Mills et al. and de Faubert Maunder et al. methods. The serum method employed was a modification of the Burse et al. method. Both breast adipose tissue and serum from 36 women were analyzed, and correlations of the residues from the two substrates were evaluated. Serum concentrations of p,p'-DDE, the primary metabolite of p,p'-DDT, were correlated (alpha = .05) with the concentrations of p,p'-DDE in human breast adipose tissue (r = .808). Serum concentrations of the PCB congener BZ 153 were also significantly correlated to the human breast adipose tissue concentrations of BZ 153 (r = .377). No significant relationship was found between serum concentrations and tissue residues for 15 of the 17 compounds analyzed. This lack of correlation between breast adipose tissue and serum, as well as an absence of the compound residues in serum, emphasized that adipose tissue should be analyzed in addition to serum to fully understand the relationship of the organochlorine compounds to breast cancer.
- Subjects :
- Aged
Aged, 80 and over
Body Burden
Breast Neoplasms etiology
Chromatography, Gas
DDT analysis
DDT blood
DDT metabolism
Dichlorodiphenyl Dichloroethylene blood
Female
Humans
Insecticides metabolism
Linear Models
Middle Aged
Pesticide Residues metabolism
Polychlorinated Biphenyls metabolism
Adipose Tissue metabolism
Breast metabolism
Insecticides analysis
Insecticides blood
Pesticide Residues analysis
Pesticide Residues blood
Polychlorinated Biphenyls analysis
Polychlorinated Biphenyls blood
Subjects
Details
- Language :
- English
- ISSN :
- 0098-4108
- Volume :
- 52
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of toxicology and environmental health
- Publication Type :
- Academic Journal
- Accession number :
- 9354175
- Full Text :
- https://doi.org/10.1080/00984109708984065