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Effects of a quick-release form of bromocriptine (Ergoset) on fasting and postprandial plasma glucose, insulin, lipid, and lipoprotein concentrations in obese nondiabetic hyperinsulinemic women.
- Source :
-
Diabetes care [Diabetes Care] 1997 Nov; Vol. 20 (11), pp. 1697-701. - Publication Year :
- 1997
-
Abstract
- Objective: To assess the effect on various aspects of carbohydrate and lipid metabolism of administering a quick-release formulation of bromocriptine (Ergoset) to obese, nondiabetic, hyperinsulinemic women.<br />Research Design and Methods: Hourly concentrations of prolactin, glucose, insulin, free fatty acid (FFA), and triglyceride were measured for 24 h before and after approximately 8 weeks of treatment with Ergoset. In addition, fasting lipid and lipoprotein concentrations and the steady-state plasma glucose (SSPG) concentration in response to a continuous infusion of somatostatin, insulin, and glucose were determined before and after Ergoset administration.<br />Results: Circulating prolactin concentrations were dramatically decreased (P < 0.001) following treatment, associated with a significant fall (P < 0.05) in 24-h-long plasma glucose, FFA, and triglyceride concentrations. Neither circulating plasma insulin concentrations nor the ability of insulin to mediate glucose disposal changed with treatment. Finally, fasting total cholesterol fell (P < 0.05) and the ratio of total to HDL cholesterol decreased (P = 0.06) in association with Ergoset treatment.<br />Conclusions: The fact that significant metabolic improvement was seen in the obese nondiabetic hyperinsulinemic women studied suggests that Ergoset could be of therapeutic benefit in clinical conditions of hyperglycemia and/or dyslipidemia.
- Subjects :
- Administration, Oral
Adult
Aged
Blood Glucose drug effects
Blood Glucose metabolism
Bromocriptine administration & dosage
Bromocriptine pharmacology
Cholesterol blood
Cholesterol metabolism
Dopamine Agonists administration & dosage
Dopamine Agonists pharmacology
Fasting
Fatty Acids, Nonesterified blood
Fatty Acids, Nonesterified metabolism
Female
Humans
Hyperinsulinism blood
Hyperinsulinism complications
Insulin metabolism
Lipid Metabolism
Lipoproteins blood
Middle Aged
Obesity blood
Obesity complications
Postprandial Period
Prolactin blood
Prolactin drug effects
Prolactin metabolism
Triglycerides blood
Triglycerides metabolism
Blood Glucose analysis
Bromocriptine therapeutic use
Dopamine Agonists therapeutic use
Hyperinsulinism drug therapy
Insulin blood
Lipids blood
Obesity drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0149-5992
- Volume :
- 20
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Diabetes care
- Publication Type :
- Academic Journal
- Accession number :
- 9353611
- Full Text :
- https://doi.org/10.2337/diacare.20.11.1697