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Proteins M6 and F1 are required for efficient invasion of group A streptococci into cultured epithelial cells.
- Source :
-
Advances in experimental medicine and biology [Adv Exp Med Biol] 1997; Vol. 418, pp. 511-5. - Publication Year :
- 1997
-
Abstract
- Group A streptococci were recently shown to be capable of invading human epithelial cell monolayers. Cell invasion might be an important virulence trait of streptococci that enable the pathogen to gain entry into deeper tissues after initial binding to host cells. Nothing is known concerning the nature of streptococcal components that mediate invasion. Using isogenic mutants of strain JRS4 that are defective in the expression of either M6 protein or protein F1, or both proteins, it was demonstrated that both adhesins are required for efficient invasion. Further more, expression of protein F1 on the surface of a non-invasive strain rendered the latter invasive, suggesting that protein F1 is directly involved in the invasion process.
- Subjects :
- Adhesins, Bacterial genetics
Adhesins, Bacterial physiology
Bacterial Adhesion genetics
Bacterial Adhesion physiology
Bacterial Proteins genetics
Cell Line
Epithelial Cells
Humans
Mutation
Streptococcus pyogenes genetics
Virulence genetics
Virulence physiology
Antigens, Bacterial
Bacterial Outer Membrane Proteins
Bacterial Proteins physiology
Carrier Proteins
Streptococcus pyogenes pathogenicity
Streptococcus pyogenes physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0065-2598
- Volume :
- 418
- Database :
- MEDLINE
- Journal :
- Advances in experimental medicine and biology
- Publication Type :
- Academic Journal
- Accession number :
- 9331705
- Full Text :
- https://doi.org/10.1007/978-1-4899-1825-3_121