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Antimetabolites produced by microorganisms. XIII. The synthesis and microbiological production of a novel amino acid, L-2-amino-4-(2-aminoethoxy) butanoic acid.
- Source :
-
The Journal of antibiotics [J Antibiot (Tokyo)] 1976 Jan; Vol. 29 (1), pp. 38-43. - Publication Year :
- 1976
-
Abstract
- A novel amino acid, L-2-amino-4-(2-aminoethoxy-)-butanoic acid, was isolated from a fermentation broth of Streptomyces sp. X-11,085. It was shown to be identical with the chemical reduction product of an antimetabolite antibiotic, L-2-amino-4-(2-aminoethoxy)-trans-3-butenoic acid, a co-product in the fermentation. Addition of the title compound to the fermentation led to an enhanced yield of the antimetabolite suggesting that the saturated amino acid serves as a precursor for the antimetabolite.
Details
- Language :
- English
- ISSN :
- 0021-8820
- Volume :
- 29
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- The Journal of antibiotics
- Publication Type :
- Academic Journal
- Accession number :
- 931793
- Full Text :
- https://doi.org/10.7164/antibiotics.29.38