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Effects of beta-carotene and canthaxanthin on aflatoxicosis in broilers.
- Source :
-
Poultry science [Poult Sci] 1997 Oct; Vol. 76 (10), pp. 1337-41. - Publication Year :
- 1997
-
Abstract
- In 2 x 3 factorial experiments, 240 broiler chicks were fed diets containing 0, 0.01, and 0.02% beta-carotene or canthaxanthin with or without 5 ppm aflatoxin to determine the effects of these two carotenoids on the health and well-being of broilers subjected to aflatoxin poisoning. Neither beta-carotene nor canthaxanthin was effective at overcoming the growth-depressing effects of aflatoxin. Relative liver weights were significantly higher in broilers receiving dietary aflatoxin in the presence of beta-carotene but not canthaxanthin. beta-Carotene and canthaxanthin had no effect on antibody production against infectious bursal disease (IBD). Interestingly, secondary antibody production against IBD was enhanced by the presence of aflatoxin in the diet. Canthaxanthin significantly increased the concentrations of cholesterol, total protein, uric acid, and triglyceride, all of which were significantly depressed by aflatoxin. beta-Carotene did not effect any of the measured blood analytes. There was a significant interaction between canthaxanthin and aflatoxin with respect to creatine kinase activity. Creatine kinase activity decreased as dietary canthaxanthin increased in the presence of aflatoxin. The data suggest that beta-carotene is not effective at ameliorating aflatoxicosis in broiler chickens but that canthaxanthin may be somewhat effective with respect to certain clinical blood chemistry indicators.
- Subjects :
- Alanine Transaminase blood
Analysis of Variance
Animals
Antibodies, Viral blood
Antibodies, Viral immunology
Antibodies, Viral metabolism
Antioxidants administration & dosage
Aspartate Aminotransferases blood
Birnaviridae Infections blood
Birnaviridae Infections immunology
Birnaviridae Infections veterinary
Canthaxanthin administration & dosage
Chickens growth & development
Cholinesterases blood
Creatine Kinase blood
Diet veterinary
Dose-Response Relationship, Drug
Drug Interactions
Enzyme-Linked Immunosorbent Assay methods
Enzyme-Linked Immunosorbent Assay veterinary
Growth drug effects
Growth physiology
Immune System drug effects
Immune System metabolism
Immune System physiology
Infectious bursal disease virus immunology
L-Lactate Dehydrogenase blood
Linear Models
Mycotoxicosis blood
Mycotoxicosis immunology
Poultry Diseases blood
Poultry Diseases immunology
beta Carotene administration & dosage
Aflatoxins toxicity
Antioxidants pharmacology
Canthaxanthin pharmacology
Chickens blood
Chickens immunology
Mycotoxicosis veterinary
beta Carotene pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0032-5791
- Volume :
- 76
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Poultry science
- Publication Type :
- Academic Journal
- Accession number :
- 9316107
- Full Text :
- https://doi.org/10.1093/ps/76.10.1337