Genetic immunization with adeno-associated virus vectors expressing herpes simplex virus type 2 glycoproteins B and D.

Authors :: Manning WC
Paliard X
Zhou S
Pat Bland M
Lee AY
Hong K
Walker CM
Escobedo JA
Dwarki V
Source :: Journal of virology [J Virol] 1997 Oct; Vol. 71 (10), pp. 7960-2.
Publication Year :: 1997
Abstract: Intramuscular injection of mice with an adeno-associated virus (AAV) vector expressing herpes simplex virus type 2 glycoprotein B led to the generation of both gB-specific major histocompatibility complex class I-restricted cytotoxic T lymphocytes and anti-gB antibody. AAV-mediated immunization was more potent than plasmid DNA or protein in generating antibody responses.

Subjects :: Animals
Antibody Formation
Cytotoxicity, Immunologic
Injections, Intramuscular
Lymphocyte Activation
Mice
Mice, Inbred C57BL
Time Factors
Viral Envelope Proteins immunology
Dependovirus
Genetic Vectors
Herpesvirus 2, Human immunology
T-Lymphocytes, Cytotoxic immunology
Vaccines, DNA administration & dosage
Viral Envelope Proteins genetics
Viral Vaccines administration & dosage

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