Segregation analysis of thalassemia in Ferrara.

Authors :: Papi C
Prampolini B
Vullo C
Barra I
Source :: American journal of human genetics [Am J Hum Genet] 1977 Nov; Vol. 29 (6), pp. 627-34.
Publication Year :: 1977
Abstract: Segregation analysis of 996 families in which the gene for beta-thalassemia was segregating showed no distortion of expected Mendelian ratios. No appreciable frequency of sporadic cases was detected. It was suggested that segregation distortion is not a mechanism which contributes to the maintenance of polymorphism in the beta-thalassemia system in the population of the Ferrara area.