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Morphometric analysis of growth retardation in fetal lambs following experimental infection of pregnant ewes with border disease virus.
- Source :
-
Research in veterinary science [Res Vet Sci] 1997 May-Jun; Vol. 62 (3), pp. 245-8. - Publication Year :
- 1997
-
Abstract
- The onset of growth retardation was investigated in fetal lambs following experimental infection of pregnant ewes with Border Disease virus (BDV) on day 53 of pregnancy. Fetuses from control and infected ewes were harvested at weekly intervals between day 60 and day 95 of gestation and morphometric studies were completed on tibial radiographs and tibial growth cartilage metaphyseal junctions. Mean tibial areas were significantly reduced (P < 0.01) in fetuses from infected ewes at 35 and 42 days after infection and growth cartilage metaphyseal junctions were less mature in fetuses from infected ewes at 42 days after infection. Positive immunostaining for BDV antigen was demonstrated in the brains of all fetuses from infected ewes between 14 and 42 days after infection. Attempts to demonstrate BDV antigen in bone proved unsuccessful. It is concluded that intrauterine growth retardation is an early manifestation of BDV infection in lambs and that the process is initiated shortly following infection of the fetus.
- Subjects :
- Animals
Antibodies, Monoclonal analysis
Antibodies, Monoclonal immunology
Antibodies, Viral analysis
Antibodies, Viral immunology
Antigens, Viral analysis
Antigens, Viral immunology
Border Disease immunology
Border Disease virology
Border disease virus immunology
Border disease virus isolation & purification
Embryonic and Fetal Development physiology
Female
Fetal Growth Retardation physiopathology
Fetal Growth Retardation virology
Gestational Age
Growth Plate cytology
Growth Plate embryology
Growth Plate growth & development
Immunohistochemistry
Pregnancy
Pregnancy Complications, Infectious physiopathology
Pregnancy Complications, Infectious virology
Radiography
Sheep
Sheep Diseases virology
Tibia diagnostic imaging
Tibia embryology
Tibia growth & development
Border Disease physiopathology
Border disease virus physiology
Fetal Growth Retardation veterinary
Pregnancy Complications, Infectious veterinary
Sheep Diseases physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 0034-5288
- Volume :
- 62
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Research in veterinary science
- Publication Type :
- Academic Journal
- Accession number :
- 9300542
- Full Text :
- https://doi.org/10.1016/s0034-5288(97)90198-3