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Prediction of protein-protein interaction sites using patch analysis.
- Source :
-
Journal of molecular biology [J Mol Biol] 1997 Sep 12; Vol. 272 (1), pp. 133-43. - Publication Year :
- 1997
-
Abstract
- A method for defining and analysing a series of residue patches on the surface of protein structures is used to predict the location of protein-protein interaction sites. Each residue patch is analysed for six parameters; solvation potential, residue interface propensity, hydrophobicity, planarity, protrusion and accessible surface area. The method involves the calculation of a relative combined score that gives the probability of a surface patch forming protein-protein interactions. Predictions are made for the known structures of protomers from 28 homo-dimers, large protomers from 11 hetero-complexes, small protomers from 14 hetero-complexes, and antigens from six antibody-antigen complexes. The predictions are successful for 66% (39/59) of the structures and the remainder can usually be rationalized in terms of additional interaction sites.<br /> (Copyright 1997 Academic Press Limited.)
Details
- Language :
- English
- ISSN :
- 0022-2836
- Volume :
- 272
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of molecular biology
- Publication Type :
- Academic Journal
- Accession number :
- 9299343
- Full Text :
- https://doi.org/10.1006/jmbi.1997.1233