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[Therapy of heart failure. II. Therapy of chronic heart failure].
- Source :
-
Fortschritte der Medizin [Fortschr Med] 1997 Jun 10; Vol. 115 (16), pp. 36-8, 41-5. - Publication Year :
- 1997
-
Abstract
- Current medical treatment of chronic heart failure makes use of a combination of diuretics, cardiac glycosides and ACE inhibitors. The latter have improved the chances of survival of patients with chronic cardiac insufficiency. The combination of hydralazine hydrochloride and isosorbide dinitrate also improves survival, but direct comparison of both regimens provided evidence for a less favourable effect than that of the ACE inhibitors. Inhibition of neuroendocrine activation has been demonstrated only for ACE inhibitors and cardiac glycosides. The use of beta blockers represents a new therapeutic strategy that over the long term improves cardiomyocyte function, cardiac output at rest, and physical performance. For this indication, however, beta blockers should be used with extreme caution and at very low initial doses. New approaches in the area of clinical research are, for example, calcium sensitizers, modulators of intracellular calcium and/or sodium homeostasis, imidazolin receptor antagonists with an action on the central nervous system and AT1 receptor antagonists.
- Subjects :
- Angiotensin-Converting Enzyme Inhibitors adverse effects
Angiotensin-Converting Enzyme Inhibitors therapeutic use
Cardiotonic Agents adverse effects
Diuretics adverse effects
Diuretics therapeutic use
Drug Therapy, Combination
Heart Failure etiology
Heart Failure physiopathology
Hemodynamics drug effects
Hemodynamics physiology
Humans
Cardiotonic Agents therapeutic use
Heart Failure drug therapy
Subjects
Details
- Language :
- German
- ISSN :
- 0015-8178
- Volume :
- 115
- Issue :
- 16
- Database :
- MEDLINE
- Journal :
- Fortschritte der Medizin
- Publication Type :
- Academic Journal
- Accession number :
- 9280747